Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141000 | 0.89 | MTOR (0.52) | MTORRPTORMLST8TACR3PARP1 | |
| SCHEMBL20140622 | 0.89 | MTOR (0.43) | MTORRPTORMLST8TACR3PRKAA2 | |
| SCHEMBL20157126 | 0.87 | MTOR (0.48) | MTORRPTORMLST8PRKAA2PARP1 | |
| SCHEMBL20140541 | 0.85 | MTOR (0.46) | MTORRPTORMLST8TACR3PRKAA2 | |
| Trifluoroacetic Acid SCHEMBL20140494 | 0.84 | PPARG (0.46) | MTORRPTORMLST8PRKAA2PARP1 | |
| SCHEMBL20156970 | 0.83 | PRKAA2 (0.47) | MTORRPTORMLST8TACR3PRKAA2 | |
| SCHEMBL20140021 | 0.82 | PRKAA2 (0.42) | MTORRPTORMLST8TACR3PRKAA2 | |
| SCHEMBL20140837 | 0.80 | DRD4 (0.48) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20157251 | 0.79 | PARP1 (0.49) | MTORRPTORMLST8PRKAA2PARP1 | |
| SCHEMBL20140388 | 0.79 | MTOR (0.47) | MTORRPTORMLST8PARP1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |