Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 8/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 5/20 | 0.39 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157126 | 0.96 | MTOR (0.48) | PPARGMTORRPTORMLST8DRD2 | |
| SCHEMBL20140738 | 0.85 | MTOR (0.54) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20140622 | 0.85 | MTOR (0.43) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20140010 | 0.84 | MTOR (0.44) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20157125 | 0.82 | MTOR (0.48) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20156964 | 0.81 | MTOR (0.49) | PPARGMTORRPTORMLST8DRD2 | |
| SCHEMBL20140576 | 0.80 | MTOR (0.48) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20140795 | 0.80 | MTOR (0.58) | MTORRPTORMLST8DRD2PARP1 | |
| SCHEMBL20139934 | 0.80 | PPARG (0.47) | PPARGMTORRPTORMLST8RET | |
| SCHEMBL20140388 | 0.79 | MTOR (0.47) | PPARGMTORRPTORMLST8DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |