Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140839 | 0.91 | POLB (0.46) | DRD2HTR2AHTR1AHTR7MTOR | |
| SCHEMBL20142472 | 0.84 | DRD2 (0.42) | HSD11B1DRD2HTR2AHTR1AHTR7 | |
| SCHEMBL20142471 | 0.84 | DRD2 (0.42) | HSD11B1DRD2HTR2AHTR1AHTR7 | |
| SCHEMBL20141897 | 0.83 | HTT (0.47) | KDM4ETDP1HTTALDH1A1PARP1 | |
| SCHEMBL20156994 | 0.81 | KDM4E (0.54) | DRD2HTR2AHTR1AHTR7MTOR | |
| SCHEMBL20140323 | 0.81 | KDM4E (0.54) | DRD2HTR2AHTR1AHTR7MTOR | |
| SCHEMBL20157254 | 0.80 | DRD2 (0.52) | HSD11B1DRD2HTR2AHTR1AHTR7 | |
| SCHEMBL20157478 | 0.80 | DRD4 (0.45) | DRD2HTR2AHTR1AHTR7MTOR | |
| SCHEMBL20140521 | 0.80 | ALDH1A1 (0.44) | HSD11B1DRD2HTR2ADRD4KDM4E | |
| SCHEMBL20157139 | 0.79 | DRD2 (0.50) | HSD11B1DRD2HTR2AHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |