Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 6/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140839 | 0.88 | POLB (0.46) | HTTKDM4EALDH1A1POLBPKM | |
| SCHEMBL20140016 | 0.83 | HSD11B1 (0.55) | HTTKDM4EALDH1A1TDP1PARP1 | |
| SCHEMBL20139969 | 0.83 | MTOR (0.49) | HTTGAATSHRKDM4EALDH1A1 | |
| SCHEMBL20156964 | 0.82 | MTOR (0.49) | HTTKDM4EPPARGPARP1RET | |
| SCHEMBL20157265 | 0.82 | RET (0.40) | PPARGPARP1PARP2TNK1RET | |
| SCHEMBL20139878 | 0.80 | PRKAA2 (0.43) | ALDH1A1PPARGRET | |
| SCHEMBL20141707 | 0.79 | MTOR (0.47) | KDM4EPPARGPARP1 | |
| SCHEMBL20139858 | 0.78 | PKM (0.47) | GAAKDM4EALDH1A1PPARGPARP1 | |
| SCHEMBL20157478 | 0.77 | DRD4 (0.45) | HTTKDM4EALDH1A1 | |
| SCHEMBL20140521 | 0.77 | ALDH1A1 (0.44) | HTTTSHRKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |