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Sugi Predict / Compounds / SCHEMBL2014009

SCHEMBL2014009

SCHEMBL2014009

Cc1cc(C2=NO[C@@](c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ RXRB P28702 3/20 0.41
▸ RXRA P19793 2/20 0.41
▸ RARB P10826 5/20 0.36
▸ RARA P10276 4/20 0.36
▸ RARG P13631 4/20 0.36
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ RECQL P46063 1/20 0.35
▸ ADRB1 P08588 1/20 0.33
▸ ADRB3 P13945 1/20 0.33
▸ PKM P14618 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ RORC P51449 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ CRBN Q96SW2 1/20 0.31
▸ PDK2 Q15119 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29385555 1.00 RXRB (0.41) RXRBRXRARARBRARARARG
SCHEMBL12274098 1.00 RXRB (0.41) RXRBRXRARARBRARARARG
SCHEMBL29397265 1.00 RXRB (0.41) RXRBRXRARARBRARARARG
SCHEMBL362701 1.00 RXRB (0.41) RXRBRXRARARBRARARARG
Hydrochloric Acid SCHEMBL1566413 0.99 RXRB (0.40) RXRBRXRARARBRARARARG
SCHEMBL22135784 0.95 RXRB (0.39) RXRBRXRARARBRARARARG
SCHEMBL2009917 0.93 RXRB (0.38) RXRBRXRARARBRARARARG
SCHEMBL2015664 0.93 RXRB (0.47) RXRBRXRARARBRARARARG
SCHEMBL2013786 0.93 RXRB (0.40) RXRBRXRARARBRARARARG
SCHEMBL15271560 0.92 CA1 (0.34) RXRBRXRACA1CA2RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548859-B2 Method for producing (5,S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4Hisoxazol-3-yl]-2-methyl-benzoic acid INTERVET INC. (US) 2023-01-10 — — US claimed
US-20220073479-A1 Method for Producing (5,S)-4-[5-(3,5-Dichlorophenyl)-5-(Trifluoromethyl)-4Hisoxazol-3-YL]-2-Methyl-Benzoic Acid INTERVET INC. (US) 2022-03-10 — — US claimed
EP-3898600-A1 METHOD FOR RACEMISATION OF (5R)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4H-ISOXAZOL-3-YL]-2-METHYL-BENZOIC ACID Intervet International B.V. (NL) 2021-10-27 — — EP claimed
EP-3898599-A1 METHOD FOR PRODUCING (5S)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4HISOXAZOL-3-YL ]-2-METHYL-BENZOIC ACID Intervet International B.V. (NL) 2021-10-27 — — EP claimed
CN-113242854-A Preparation method of (5S) -4- [5- (3, 5-dichlorophenyl) -5- (trifluoromethyl) -4H-isoxazol-3-yl ] -2-methylbenzoic acid 英特维特国际股份有限公司 2021-08-10 — — CN claimed
CN-113195459-A Process for the racemisation of (5R) -4- [5- (3, 5-dichlorophenyl) -5- (trifluoromethyl) -4H isoxazol-3-yl ] -2-methyl-benzoic acid 英特维特国际股份有限公司 2021-07-30 — — CN claimed
WO-2020127935-A1 METHOD FOR PRODUCING (5S)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4HISOXAZOL-3-YL]-2-METHYL-BENZOIC ACID INTERVET INTERNATIONAL B.V. (NL) 2020-06-25 — — WO claimed
WO-2020127944-A1 METHOD FOR RACEMISATION OF (5R)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4H-ISOXAZOL-3-YL]-2-METHYL-BENZOIC ACID INTERVET INTERNATIONAL B.V. (NL) 2020-06-25 — — WO claimed
JP-2024167399-A Method for preparing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid インターベット インターナショナル ベー． フェー． 2024-12-03 — — JP disclosed
JP-2024167399-A Method for preparing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid インターベット インターナショナル ベー． フェー． 2024-12-03 — — JP disclosed
EP-3898598-B1 METHOD FOR PRODUCING (5S)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4H-ISOXAZOL-3-YL]-2-METHYL-BENZOIC ACID INTERVET INT BV (NL) 2024-09-11 — — EP disclosed
EP-3898598-B1 METHOD FOR PRODUCING (5S)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4H-ISOXAZOL-3-YL]-2-METHYL-BENZOIC ACID INTERVET INT BV (NL) 2024-09-11 — — EP disclosed
US-11548859-B2 Method for producing (5,S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4Hisoxazol-3-yl]-2-methyl-benzoic acid INTERVET INC. (US) 2023-01-10 — — US disclosed
US-11548859-B2 Method for producing (5,S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4Hisoxazol-3-yl]-2-methyl-benzoic acid INTERVET INC. (US) 2023-01-10 — — US disclosed
US-20140350261-A1 METHOD FOR CATALYTIC ASYMMETRIC SYNTHESIS OF OPTICALLY ACTIVE ISOXAZOLINE COMPOUND, AND OPTICALLY ACTIVE ISOXAZOLINE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-11-27 — — US disclosed
US-20140228577-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2014-08-14 — — US disclosed
US-8735362-B2 Insecticidal compounds based on isoxazoline derivatives SYNGENTA CROP PROTECTION, LLC (US) 2014-05-27 — — US disclosed
EP-2507230-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES Syngenta Participations AG (CH) 2012-10-10 — — EP disclosed
US-20120238517-A1 INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2012-09-20 — — US disclosed
WO-2011067272-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2011-06-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140228577-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES CHRM1, ACHE, CHRM2 RXRB 2327/4885RXRA 1954/4885RARB 3665/4885
US-20120238517-A1 INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES CHRM1, ACHE, CHRM2 RXRB 4311/4885RXRA 4034/4885RARB 4669/4885
US-20220073479-A1 Method for Producing (5,S)-4-[5-(3,5-Dichlorophenyl)-5-(Trifluoromethyl)-4Hisoxazol-3-YL]-2-Methyl-Benzoic Acid KDM5A, GABRA5, KDM5B RXRB 1393/4885RXRA 659/4885RARB 1299/4885
US-11548859-B2 Method for producing (5,S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4Hisoxazol-3-yl]-2-methyl-benzoic acid GABRA5, KDM5A, KDM5B RXRB 1546/4885RXRA 665/4885RARB 1282/4885
US-20140350261-A1 METHOD FOR CATALYTIC ASYMMETRIC SYNTHESIS OF OPTICALLY ACTIVE ISOXAZOLINE COMPOUND, AND OPTICALLY ACTIVE ISOXAZOLINE COMPOUND CYP3A7, CYP2A7, CYP8B1 RXRB 1629/4885RXRA 1559/4885RARB 1700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.