Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.45 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141417 | 0.75 | MEN1 (0.48) | MEN1KMT2ATP53MAPTALOX5 | |
| SCHEMBL20141780 | 0.73 | DRD4 (0.46) | DRD4DRD2DRD3KMT2ACYP3A4 | |
| SCHEMBL20141590 | 0.72 | HTR6 (0.46) | HTR6DRD4DRD2DRD3MEN1 | |
| SCHEMBL20139958 | 0.71 | NAMPT (0.53) | DRD4DRD2DRD3MEN1KMT2A | |
| SCHEMBL20140911 | 0.71 | HTR6 (0.44) | HTR6DRD4DRD2DRD3ALOX5 | |
| SCHEMBL20141270 | 0.71 | HTR6 (0.44) | HTR6DRD4DRD2DRD3ALOX5 | |
| SCHEMBL20139884 | 0.71 | BDKRB1 (0.47) | DRD4DRD2DRD3CYP3A4CYP2D6 | |
| SCHEMBL20141541 | 0.70 | MTOR (0.48) | DRD4DRD2DRD3MAPTKDM4E | |
| SCHEMBL20157267 | 0.70 | DRD4 (0.52) | DRD4DRD2DRD3CYP3A4CYP2D6 | |
| SCHEMBL20140762 | 0.69 | HTR6 (0.47) | HTR6DRD4DRD2DRD3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |