Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142330 | 0.87 | HTR6 (0.45) | HTR6DRD4MTORRPTORMLST8 | |
| SCHEMBL20141590 | 0.87 | HTR6 (0.46) | HTR6DRD4MTORRPTORMLST8 | |
| SCHEMBL20140911 | 0.85 | HTR6 (0.44) | HTR6DRD4MTORRPTORMLST8 | |
| SCHEMBL20141270 | 0.85 | HTR6 (0.44) | HTR6DRD4MTORRPTORMLST8 | |
| SCHEMBL20140569 | 0.83 | MTOR (0.51) | DRD4MTORRPTORMLST8DRD2 | |
| SCHEMBL20157163 | 0.79 | MTOR (0.45) | DRD4MTORRPTORMLST8DRD2 | |
| Trifluoroacetic Acid SCHEMBL20140610 | 0.78 | MTOR (0.49) | DRD4MTORRPTORMLST8DRD2 | |
| SCHEMBL20157291 | 0.77 | PARP1 (0.45) | DRD4MTORRPTORMLST8DRD2 | |
| SCHEMBL20141863 | 0.76 | MTOR (0.53) | DRD4MTORRPTORMLST8DRD2 | |
| SCHEMBL20157134 | 0.76 | ALDH1A1 (0.40) | HTR6DRD4MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |