Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10533047 | 0.77 | ALOX5AP (0.53) | ALDH1A1MAPTPTGS2HSD17B10ALOX5AP | |
| SCHEMBL5352962 | 0.76 | HTR7 (0.69) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL27876080 | 0.75 | HTR7 (0.67) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL13039956 | 0.75 | HTR7 (0.67) | HTR6HTR7HTR1AHTR2AHTR5A | |
| Hydrochloric Acid SCHEMBL27892728 | 0.73 | HTR7 (0.65) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL31402471 | 0.73 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1KDM4EMAPTKEAP1 | |
| SCHEMBL4914927 | 0.73 | HTR7 (0.73) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL28618211 | 0.73 | KDM4E (0.41) | ALDH1A1L3MBTL1KDM4ETDP1MAPT | |
| SCHEMBL19308566 | 0.73 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1TDP1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL6570766 | 0.71 | ALDH1A1 (0.57) | HTR6HTR7HTR1AHTR2AHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538522-A1 | ROR GAMMA MODULATORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |