Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.53 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140485 | 0.87 | ITGB1 (0.51) | ITGB1ITGA4CHRNA7SMN1; SMN2ITGB3 | |
| SCHEMBL20140536 | 0.78 | ITGB1 (0.51) | ITGB1ITGA4CHRNA7SMN1; SMN2ITGB3 | |
| SCHEMBL21314393 | 0.76 | ITGB1 (0.47) | ITGB1ITGA4CHRNA7SMN1; SMN2ITGB3 | |
| SCHEMBL20140807 | 0.75 | ITGB3 (0.62) | ITGB1ITGB3ITGA2BITGAV | |
| SCHEMBL21317545 | 0.75 | ITGB3 (0.62) | ITGB1ITGB3ITGA2BITGAV | |
| SCHEMBL20142834 | 0.75 | ITGB1 (0.43) | ITGB1ITGA4CHRNA7ITGB3ITGA2B | |
| SCHEMBL20158050 | 0.75 | ITGB3 (0.62) | ITGB1ITGB3ITGA2BITGAV | |
| SCHEMBL20140803 | 0.75 | ITGB3 (0.62) | ITGB1ITGB3ITGA2BITGAV | |
| SCHEMBL29701366 | 0.75 | ITGB3 (0.62) | ITGB1ITGB3ITGA2BITGAV | |
| SCHEMBL29701370 | 0.75 | ITGB1 (0.43) | ITGB1ITGA4CHRNA7ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |