Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.51 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140775 | 0.85 | DRD4 (0.51) | DRD4HRH2POLBMEN1KMT2A | |
| SCHEMBL20140126 | 0.83 | MTOR (0.53) | DRD4KCNH2MTORRPTORMLST8 | |
| SCHEMBL20140057 | 0.83 | MTOR (0.51) | DRD4MTORRPTORMLST8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20140671 | 0.82 | MTOR (0.52) | DRD4KCNH2MTORRPTORMLST8 | |
| SCHEMBL20141432 | 0.79 | MTOR (0.50) | DRD4KCNH2MTORRPTORMLST8 | |
| SCHEMBL20156997 | 0.78 | MTOR (0.44) | DRD4MTORRPTORMLST8 | |
| SCHEMBL20156833 | 0.77 | DRD4 (0.41) | DRD4ADRA1DADRA1AADRA1BMTOR | |
| SCHEMBL20141367 | 0.76 | RET (0.42) | DRD4 | |
| SCHEMBL20140782 | 0.74 | CHRM4 (0.44) | DRD4MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20140342 | 0.74 | MTOR (0.56) | DRD4MTORRPTORMLST8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |