Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 9/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141367 | 0.86 | RET (0.42) | DRD4RET | |
| SCHEMBL20140482 | 0.77 | DRD4 (0.51) | DRD4MTORRPTORMLST8PROKR1 | |
| SCHEMBL20140777 | 0.77 | DRD4 (0.43) | DRD4MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20140057 | 0.75 | MTOR (0.51) | DRD4MTORRPTORMLST8FASN | |
| SCHEMBL20141538 | 0.74 | DRD4 (0.41) | DRD4MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20139980 | 0.74 | MTOR (0.46) | DRD4RETMTORRPTORMLST8 | |
| SCHEMBL20141546 | 0.73 | MTOR (0.47) | DRD4MTORRPTORMLST8 | |
| SCHEMBL20156997 | 0.73 | MTOR (0.44) | DRD4RETMTORRPTORMLST8 | |
| SCHEMBL20156791 | 0.71 | MTOR (0.52) | DRD4MTORRPTORMLST8HCRTR1 | |
| SCHEMBL20140996 | 0.70 | MTOR (0.44) | DRD4MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |