Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141811 | 0.93 | PPARG (0.46) | PPARGPPARAHSD17B10MTORRPTOR | |
| SCHEMBL20141929 | 0.92 | PPARG (0.47) | PPARGHSD17B10MTORRPTORMLST8 | |
| SCHEMBL20140812 | 0.91 | ALDH1A1 (0.56) | HSD17B10MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL20157329 | 0.90 | PPARA (0.49) | PPARAHSD17B10MTORRPTORMLST8 | |
| SCHEMBL20140429 | 0.88 | MTOR (0.48) | MTORRPTORMLST8MEN1NPC1 | |
| SCHEMBL20141948 | 0.86 | SMN1; SMN2 (0.51) | MEN1MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL20141688 | 0.84 | MTOR (0.48) | MTORRPTORMLST8MAPTKMT2A | |
| SCHEMBL20157304 | 0.82 | MTOR (0.47) | MTORRPTORMLST8ALDH1A1KDM4E | |
| SCHEMBL20140585 | 0.82 | PPARG (0.47) | PPARGPPARDPPARAMTORRPTOR | |
| SCHEMBL20141357 | 0.82 | MTOR (0.43) | MTORRPTORMLST8MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |