Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156887 | 0.92 | PPARG (0.46) | PPARGPPARAMTORRPTORMLST8 | |
| SCHEMBL20139934 | 0.90 | PPARG (0.47) | PPARGMTORRPTORMLST8RET | |
| SCHEMBL20140697 | 0.89 | PPARA (0.49) | PPARAMTORRPTORMLST8RET | |
| SCHEMBL20140044 | 0.88 | MTOR (0.54) | TACR3MTORRPTORMLST8DRD2 | |
| SCHEMBL20156931 | 0.87 | MTOR (0.51) | TACR3MTORRPTORMLST8USP2 | |
| SCHEMBL20141182 | 0.85 | PARP1 (0.48) | TACR3MTORRPTORMLST8DRD2 | |
| SCHEMBL20139930 | 0.85 | MTOR (0.53) | MTORRPTORMLST8USP2TSHR | |
| SCHEMBL20140664 | 0.84 | MTOR (0.57) | TACR3MTORRPTORMLST8DRD2 | |
| SCHEMBL20156970 | 0.84 | PRKAA2 (0.47) | TACR3MTORRPTORMLST8RET | |
| SCHEMBL20140785 | 0.83 | PARP1 (0.47) | MTORRPTORMLST8PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |