Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141295 | 0.89 | KDM4E (0.50) | SMN1; SMN2LMNAALDH1A1HTTKDM4E | |
| SCHEMBL20141688 | 0.89 | MTOR (0.48) | SMN1; SMN2LMNAHTTKDM4EKMT2A | |
| SCHEMBL20140812 | 0.87 | ALDH1A1 (0.56) | SMN1; SMN2LMNAALDH1A1HTTKDM4E | |
| SCHEMBL20140645 | 0.86 | PPARG (0.49) | TRPA1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20141811 | 0.84 | PPARG (0.46) | SMN1; SMN2LMNAALDH1A1HTTKDM4E | |
| SCHEMBL20140429 | 0.84 | MTOR (0.48) | SMN1; SMN2TRPA1ALDH1A1HTTKDM4E | |
| SCHEMBL20141929 | 0.83 | PPARG (0.47) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL20140664 | 0.83 | MTOR (0.57) | ALDH1A1HTTKDM4ENPSR1HTR1A | |
| SCHEMBL20141357 | 0.83 | MTOR (0.43) | TRPA1MEN1KMT2AMAPT | |
| SCHEMBL20157304 | 0.82 | MTOR (0.47) | SMN1; SMN2ALDH1A1HTTKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |