Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.37 |
| ▸ | KHK | P50053 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140655 | 1.00 | PIM1 (0.41) | PIM1PIM2PIM3ACKR3MKNK1 | |
| SCHEMBL17889308 | 0.80 | KHK (0.40) | PIM1PIM2PIM3ALDH1A1LMNA | |
| SCHEMBL20141437 | 0.75 | HTR1A (0.44) | PIM1PIM2PIM3ROCK2ALDH1A1 | |
| SCHEMBL20141435 | 0.75 | HTR1A (0.44) | PIM1PIM2PIM3ROCK2ALDH1A1 | |
| SCHEMBL4244446 | 0.75 | HTR6 (0.61) | ALDH1A1LMNAPRKCQPRKCDKHK | |
| SCHEMBL4247868 | 0.75 | HTR6 (0.61) | ALDH1A1LMNAPRKCQPRKCDKHK | |
| SCHEMBL4244450 | 0.75 | HTR6 (0.61) | ALDH1A1LMNAPRKCQPRKCDKHK | |
| SCHEMBL14146963 | 0.74 | PRKCQ (0.59) | PIM1PIM2ALDH1A1LMNAPRKCQ | |
| SCHEMBL23602033 | 0.73 | HTR2A (0.65) | ROCK2ALDH1A1LMNAPRKCQPRKCD | |
| SCHEMBL4243080 | 0.71 | HTR2C (0.58) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |