Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140600 | 0.93 | KDM4E (0.54) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20156931 | 0.91 | MTOR (0.51) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20140023 | 0.89 | MTOR (0.61) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20139966 | 0.89 | MTOR (0.61) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20140044 | 0.88 | MTOR (0.54) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20157309 | 0.88 | MTOR (0.47) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20156810 | 0.88 | MTOR (0.47) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20140812 | 0.85 | ALDH1A1 (0.56) | KDM4EALDH1A1HTR7CHRM4GAA | |
| SCHEMBL20141295 | 0.85 | KDM4E (0.50) | MTORRPTORMLST8DRD2HTR2A | |
| SCHEMBL20157539 | 0.84 | MTOR (0.46) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |