Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140659 | 0.80 | PLAT (0.40) | ALDH1A1SMN1; SMN2MAPTCHRM1CHRM2 | |
| SCHEMBL4247366 | 0.79 | GBA1 (0.51) | SLC6A4ALDH1A1SMN1; SMN2GBA1KDM4E | |
| Hydrochloric Acid SCHEMBL4777910 | 0.78 | GBA1 (0.50) | SLC6A4ALDH1A1SMN1; SMN2GBA1KDM4E | |
| SCHEMBL17595529 | 0.77 | LOXL2 (0.55) | SLC6A4ALDH1A1SMN1; SMN2GBA1KDM4E | |
| SCHEMBL12488798 | 0.77 | KDM4E (0.42) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL29185103 | 0.77 | GBA1 (0.55) | P2RX7SLC6A4GBA1PRMT5WDR77 | |
| SCHEMBL30781482 | 0.77 | GBA1 (0.55) | P2RX7SLC6A4GBA1PRMT5WDR77 | |
| SCHEMBL20140685 | 0.77 | EED (0.48) | ALDH1A1KDM4EMAPTCYP2C9CYP2C19 | |
| SCHEMBL12961528 | 0.76 | SLC6A4 (0.56) | SLC6A4GBA1 | |
| SCHEMBL15999757 | 0.75 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |