Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 6/20 | 0.64 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456832 | 0.80 | GRM1 (0.56) | GRM1HCRTR1HCRTR2GRM5HTR7 | |
| SCHEMBL5369598 | 0.80 | GRM5 (0.60) | GRM5DRD2DRD4DPP4MC4R | |
| SCHEMBL20140595 | 0.78 | GRM1 (0.50) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL20139540 | 0.78 | GRM1 (0.47) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL20141122 | 0.76 | GRM1 (0.48) | GRM1GRM5DRD2DRD4DPP4 | |
| SCHEMBL30619380 | 0.75 | GRM1 (0.49) | GRM1GRM5DRD2DRD4HTR7 | |
| SCHEMBL27488325 | 0.75 | GRM1 (0.49) | GRM1GRM5DRD2DRD4HTR7 | |
| SCHEMBL1394196 | 0.75 | RBP4 (0.57) | HCRTR1HCRTR2NOTUM | |
| SCHEMBL21667804 | 0.74 | BPTF (0.53) | GRM1GRM5DRD2DRD4HTR7 | |
| SCHEMBL20141154 | 0.74 | GRM1 (0.48) | GRM1GRM5DRD2DRD4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |