Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140652 | 0.87 | PHGDH (0.45) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20139913 | 0.81 | DRD4 (0.47) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20133677 | 0.81 | MTOR (0.44) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20139817 | 0.77 | RXFP1 (0.52) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20140073 | 0.75 | TACR3 (0.49) | PHGDHKDM4EALDH1A1ARLMNA | |
| SCHEMBL3088832 | 0.74 | DRD4 (0.54) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL20157090 | 0.73 | DRD4 (0.47) | KDM4EDRD4DRD2DRD3ALDH1A1 | |
| SCHEMBL2077260 | 0.70 | GRM5 (0.51) | PHGDHKDM4EDRD4DRD2DRD3 | |
| SCHEMBL2077261 | 0.70 | ADRA2C (0.56) | DRD4DRD2DRD3HTR2AAR | |
| SCHEMBL20156961 | 0.70 | DRD2 (0.49) | PHGDHKDM4EDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |