Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524209 | 0.93 | HTR3E (0.47) | GRIN2BHCRTR1HCRTR2GPBAR1HTR3E | |
| SCHEMBL20142336 | 0.87 | GRM1 (0.47) | DRD3ACACBDGAT2GRM1 | |
| SCHEMBL27128220 | 0.83 | GRM1 (0.52) | HTR1AHTR2ADRD3KDM4ERECQL | |
| SCHEMBL5652856 | 0.79 | GRIN2D (0.42) | GRIN2BPARP1KDM4EGRM1 | |
| SCHEMBL4531399 | 0.78 | CHRM4 (0.51) | HCRTR1HCRTR2HTR1AHTR2ADRD3 | |
| SCHEMBL27131408 | 0.76 | MAPT (0.40) | KDM4ERECQL | |
| SCHEMBL20141642 | 0.76 | HTR3E (0.56) | HCRTR1HCRTR2HTR3EHTR3BHTR3A | |
| SCHEMBL15205472 | 0.75 | CHRM4 (0.42) | GRIN2BACACBKDM4EGRM1 | |
| SCHEMBL20142342 | 0.75 | NOTUM (0.51) | HTR1ADRD3 | |
| SCHEMBL4009517 | 0.74 | POLB (0.43) | HTR1AHTR2APARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |