Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881604 | 0.77 | ADRA2C (0.45) | NOTUMMEN1KMT2ASMN1; SMN2RIPK1 | |
| SCHEMBL17491559 | 0.77 | ADRA2C (0.45) | NOTUMMEN1KMT2ASMN1; SMN2RIPK1 | |
| SCHEMBL27131408 | 0.77 | MAPT (0.40) | NOTUMMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL27128220 | 0.77 | GRM1 (0.52) | HTR1ADRD2DRD4SMN1; SMN2DRD3 | |
| SCHEMBL2327343 | 0.76 | RBP4 (0.37) | NOTUMMEN1CRHBPKMT2ACRHR2 | |
| SCHEMBL27130857 | 0.76 | NOTUM (0.48) | NOTUMMEN1KMT2AHTR1ADRD2 | |
| SCHEMBL4558300 | 0.75 | SLC6A9 (0.44) | HTR1ADRD2DRD4LMNADRD3 | |
| SCHEMBL2760636 | 0.75 | DRD2 (0.51) | MEN1KMT2AHTR1ADRD2SMN1; SMN2 | |
| SCHEMBL20140757 | 0.75 | GRIN2B (0.44) | HTR1ADRD3 | |
| SCHEMBL29252729 | 0.75 | AGTR2 (0.48) | NOTUMMEN1KMT2ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |