Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.60 |
| ▸ | SKP1 | P63208 | 2/20 | 0.60 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524210 | 0.95 | CKS1B (0.57) | CKS1BSKP1SKP2MAP4K4GRM5 | |
| SCHEMBL461584 | 0.87 | CKS1B (0.62) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL1481924 | 0.87 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL23104148 | 0.87 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL20142337 | 0.87 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL4298159 | 0.86 | CKS1B (0.64) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL1532924 | 0.82 | GPR119 (0.57) | GRM5TGM2GPR119 | |
| SCHEMBL29664252 | 0.82 | CKS1B (0.57) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL461585 | 0.82 | CKS1B (0.60) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL4949224 | 0.82 | CKS1B (0.57) | CKS1BSKP1SKP2MAP4K4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |