Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.64 |
| ▸ | SKP1 | P63208 | 2/20 | 0.64 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295070 | 0.95 | CKS1B (0.61) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL20140758 | 0.86 | CKS1B (0.60) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL25233588 | 0.85 | CKS1B (0.58) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL461584 | 0.85 | CKS1B (0.62) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL1481924 | 0.85 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL23104148 | 0.85 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL20142337 | 0.85 | CKS1B (0.59) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL461585 | 0.83 | CKS1B (0.60) | CKS1BSKP1SKP2MAP4K4GPR119 | |
| SCHEMBL3467261 | 0.82 | CKS1B (0.52) | CKS1BSKP1SKP2MAP4K4PDE10A | |
| SCHEMBL3467257 | 0.82 | CKS1B (0.52) | CKS1BSKP1SKP2MAP4K4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098576-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | PFIZER INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | HTR6, HTR5A, TPH1 | CKS1B 2221/4885SKP1 1913/4885SKP2 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.