Sugi Predict

Sugi Predict / Compounds / SCHEMBL20140978

SCHEMBL20140978

SCHEMBL20140978

CC(C)(C)[Si](C)(C)OC[C@@H]1CN(C(=O)O)CCN1c1ccc(F)cn1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 1/20 0.39
▸ RPTOR Q8N122 1/20 0.39
▸ MLST8 Q9BVC4 1/20 0.39
▸ CHRM1 P11229 1/20 0.39
▸ HRH3 Q9Y5N1 2/20 0.38
▸ PPARG P37231 1/20 0.36
▸ ME2 P23368 1/20 0.36
▸ ME1 P48163 1/20 0.36
▸ ME3 Q16798 1/20 0.36
▸ HDAC8 Q9BY41 2/20 0.35
▸ HDAC6 Q9UBN7 2/20 0.35
▸ PDK2 Q15119 1/20 0.35
▸ NR1H2 P55055 2/20 0.34
▸ NR1H3 Q13133 2/20 0.34
▸ GRM1 Q13255 2/20 0.33
▸ ADRA1A P35348 1/20 0.33
▸ CHRM4 P08173 1/20 0.33
▸ SLC27A1 Q6PCB7 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21360351 0.89 HDAC8 (0.44) MTORRPTORMLST8CHRM1HRH3
SCHEMBL22159416 0.84 GRM1 (0.41) MTORRPTORMLST8GRM1HPGD
SCHEMBL20141130 0.79 CHRM2 (0.36) CHRM1CHRM4
SCHEMBL20141457 0.77 CYP2D6 (0.36) HDAC8HDAC6
SCHEMBL27189864 0.74 CACNA1G (0.33) HRH3NR1H2NR1H3
SCHEMBL21824617 0.74 MAPK1 (0.31) HPGD
SCHEMBL21824616 0.74 MAPK1 (0.31) HPGD
SCHEMBL21360409 0.73 GPR119 (0.51) HDAC8HDAC6GRM1
SCHEMBL29988095 0.71 — —
SCHEMBL1736316 0.71 NR1H2 (0.52) HRH3NR1H2NR1H3HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.