Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.46 |
| ▸ | GPR6 | P46095 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141164 | 0.87 | MTOR (0.46) | MTORRPTORMLST8PARP1TACR3 | |
| SCHEMBL20141054 | 0.82 | MTOR (0.48) | MTORRPTORMLST8PARP1TACR3 | |
| SCHEMBL20141074 | 0.78 | SLC6A2 (0.42) | CYP2D6 | |
| SCHEMBL20141597 | 0.76 | MTOR (0.54) | MTORRPTORMLST8PARP1LMNA | |
| Trifluoroacetic Acid SCHEMBL21340101 | 0.76 | MTOR (0.67) | MTORRPTORMLST8GPR6 | |
| SCHEMBL20141263 | 0.75 | MTOR (0.46) | MTORRPTORMLST8PARP1LMNA | |
| SCHEMBL20140929 | 0.74 | MTOR (0.57) | MTORRPTORMLST8GPR6RBP4 | |
| SCHEMBL20141049 | 0.74 | SLC6A2 (0.38) | GRM5ALDH1A1 | |
| SCHEMBL20140972 | 0.74 | MTOR (0.56) | MTORRPTORMLST8TACR3LMNA | |
| SCHEMBL20140851 | 0.73 | MTOR (0.44) | MTORRPTORMLST8CYP3A4RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |