Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141164 | 0.88 | MTOR (0.46) | MTORRPTORMLST8TP53TACR3 | |
| SCHEMBL20140929 | 0.82 | MTOR (0.57) | MTORRPTORMLST8TP53TACR3 | |
| Trifluoroacetic Acid SCHEMBL20141119 | 0.82 | MTOR (0.46) | MTORRPTORMLST8TP53TACR3 | |
| SCHEMBL20141263 | 0.81 | MTOR (0.46) | MTORRPTORMLST8MAPTPARP1 | |
| SCHEMBL20141228 | 0.81 | MTOR (0.45) | MTORRPTORMLST8TACR3GRM5 | |
| SCHEMBL20140814 | 0.80 | MTOR (0.45) | MTORRPTORMLST8TP53TACR3 | |
| SCHEMBL20141624 | 0.80 | KDM4E (0.42) | TP53ALDH1A1GAASMN1; SMN2MAPT | |
| SCHEMBL20141253 | 0.79 | TSHR (0.43) | TP53ALDH1A1HSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL20141443 | 0.79 | MTOR (0.45) | MTORRPTORMLST8ALDH1A1SMN1; SMN2 | |
| SCHEMBL20140972 | 0.79 | MTOR (0.56) | MTORRPTORMLST8TACR3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |