Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139799 | 0.80 | POLB (0.46) | ALDH1A1KDM4EPOLBL3MBTL1MAPK1 | |
| SCHEMBL11195205 | 0.76 | KDM4E (0.45) | ALDH1A1KDM4EPOLBRAB9AL3MBTL1 | |
| SCHEMBL27252487 | 0.72 | ERN1 (0.46) | ALDH1A1KDM4EL3MBTL1MEN1CYP1A2 | |
| SCHEMBL22031809 | 0.70 | L3MBTL1 (0.55) | ALDH1A1KDM4ERAB9AL3MBTL1MEN1 | |
| SCHEMBL26088044 | 0.70 | KMT2A (0.48) | ALDH1A1KDM4EL3MBTL1MAPTMAPK1 | |
| SCHEMBL11193741 | 0.69 | KDM4E (0.49) | ALDH1A1KDM4EL3MBTL1CYP3A4GAA | |
| SCHEMBL2518213 | 0.69 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBRAB9AL3MBTL1 | |
| SCHEMBL18348299 | 0.68 | KDM4E (0.47) | ALDH1A1KDM4EL3MBTL1CYP3A4MAPT | |
| SCHEMBL2174007 | 0.68 | NPC1 (0.44) | ALDH1A1KDM4ERAB9AL3MBTL1MEN1 | |
| SCHEMBL31056227 | 0.67 | ERN1 (0.38) | ALDH1A1KDM4EERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |