Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.46 |
| ▸ | CASP6 | P55212 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | APEX1 | P27695 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141338 | 0.80 | ALDH1A1 (0.50) | POLBL3MBTL1KDM4ECTDSP1CASP6 | |
| SCHEMBL2682378 | 0.79 | MCL1 (0.40) | POLBL3MBTL1KDM4ECTDSP1CASP6 | |
| SCHEMBL2497506 | 0.75 | HSD17B10 (0.47) | L3MBTL1KDM4EHSD17B10GFERALDH1A1 | |
| SCHEMBL2518213 | 0.73 | ALDH1A1 (0.57) | POLBL3MBTL1KDM4ECTDSP1CASP6 | |
| SCHEMBL20142393 | 0.72 | MEN1 (0.56) | POLBCTDSP1HSD17B10ALDH1A1LMNA | |
| SCHEMBL689571 | 0.69 | MCL1 (0.53) | POLBL3MBTL1KDM4ECTDSP1HSD17B10 | |
| SCHEMBL8989151 | 0.67 | KMT2A (0.44) | POLBL3MBTL1CTDSP1ALDH1A1TDP1 | |
| SCHEMBL28091345 | 0.67 | HSD17B10 (0.40) | POLBL3MBTL1KDM4EHSD17B10GFER | |
| SCHEMBL20158903 | 0.66 | HSD17B10 (0.39) | L3MBTL1KDM4EHSD17B10GFERALDH1A1 | |
| SCHEMBL11193555 | 0.65 | HSD17B10 (0.46) | KDM4EHSD17B10GFERALDH1A1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |