Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140898 | 0.81 | SLC6A4 (0.41) | MEN1KMT2ACYP2D6 | |
| SCHEMBL20141029 | 0.80 | SLC6A2 (0.38) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL20141054 | 0.79 | MTOR (0.48) | MTORRPTORMLST8ALDH1A1SMN1; SMN2 | |
| SCHEMBL20133681 | 0.78 | MTOR (0.65) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20141216 | 0.76 | SLC6A2 (0.38) | — | |
| SCHEMBL20141214 | 0.76 | SLC6A2 (0.38) | — | |
| SCHEMBL20141181 | 0.75 | SLC6A4 (0.41) | MEN1KMT2ACYP2D6 | |
| SCHEMBL20149880 | 0.75 | MTOR (0.62) | MTORRPTORMLST8DRD4DRD2 | |
| SCHEMBL20141038 | 0.75 | KCNH2 (0.37) | ALDH1A1KDM4ECYP2D6SMN1; SMN2 | |
| SCHEMBL20141036 | 0.75 | KCNH2 (0.37) | ALDH1A1KDM4ECYP2D6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |