Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141866 | 0.86 | MTOR (0.48) | P2RX7PDK2MTORRPTORMLST8 | |
| SCHEMBL20157059 | 0.81 | DRD4 (0.50) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20140606 | 0.81 | MTOR (0.44) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20157060 | 0.79 | DRD4 (0.43) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20141863 | 0.73 | MTOR (0.53) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20141649 | 0.73 | P2RX7 (0.47) | P2RX7MTORRPTORMLST8TACR3 | |
| SCHEMBL20141539 | 0.72 | PARP1 (0.46) | MTORRPTORMLST8DRD4 | |
| SCHEMBL20141956 | 0.72 | MTOR (0.46) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20140044 | 0.72 | MTOR (0.54) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20139982 | 0.70 | MTOR (0.50) | MTORRPTORMLST8TACR3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |