Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140044 | 0.84 | MTOR (0.54) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20141539 | 0.81 | PARP1 (0.46) | MTORRPTORMLST8HTTPARP1 | |
| SCHEMBL20140693 | 0.80 | HCRTR1 (0.49) | MTORRPTORMLST8HTTPARP1 | |
| SCHEMBL20156931 | 0.80 | MTOR (0.51) | MTORRPTORMLST8TACR3DRD2 | |
| SCHEMBL20157539 | 0.79 | MTOR (0.46) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20139955 | 0.78 | KDM4E (0.52) | MTORRPTORMLST8HTR1ADRD2 | |
| SCHEMBL20140600 | 0.78 | KDM4E (0.54) | MTORRPTORMLST8HTR1ADRD2 | |
| SCHEMBL20156809 | 0.78 | MTOR (0.45) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20140883 | 0.78 | SIGMAR1 (0.44) | MTORRPTORMLST8MEN1KMT2A | |
| SCHEMBL20157021 | 0.78 | SLC6A7 (0.46) | MTORRPTORMLST8PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |