Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141091 | 0.88 | MTOR (0.45) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20140929 | 0.82 | MTOR (0.57) | MTORRPTORMLST8PARP1CA12 | |
| SCHEMBL20140932 | 0.80 | MTOR (0.56) | MTORRPTORMLST8PARP1CA12 | |
| SCHEMBL20141263 | 0.80 | MTOR (0.46) | MTORRPTORMLST8PARP1CA12 | |
| SCHEMBL20141228 | 0.79 | MTOR (0.45) | MTORRPTORMLST8PARP1CA12 | |
| SCHEMBL20140981 | 0.78 | MTOR (0.46) | MTORRPTORMLST8SMOCA12 | |
| SCHEMBL20133696 | 0.78 | MTOR (0.67) | MTORRPTORMLST8HCRTR1HCRTR2 | |
| SCHEMBL20140814 | 0.78 | MTOR (0.45) | MTORRPTORMLST8PARP1CA12 | |
| SCHEMBL20141403 | 0.77 | MTOR (0.43) | MTORRPTORMLST8PARP1LMNA | |
| SCHEMBL20141317 | 0.77 | MTOR (0.46) | MTORRPTORMLST8PARP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |