Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.45 |
| ▸ | FASN | P49327 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | SMO | Q99835 | 3/20 | 0.34 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141671 | 0.88 | MTOR (0.44) | MTORRPTORMLST8PARP1HCRTR2 | |
| SCHEMBL20133688 | 0.79 | MTOR (0.69) | MTORRPTORMLST8HCRTR2HCRTR1 | |
| SCHEMBL20140969 | 0.76 | MTOR (0.43) | MTORRPTORMLST8FASN | |
| SCHEMBL20140929 | 0.76 | MTOR (0.57) | MTORRPTORMLST8PARP1KDM4E | |
| SCHEMBL20140898 | 0.73 | SLC6A4 (0.41) | — | |
| SCHEMBL20141225 | 0.73 | MTOR (0.41) | MTORRPTORMLST8PARP1ALDH1A1 | |
| SCHEMBL20141029 | 0.72 | SLC6A2 (0.38) | HCRTR2HCRTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20141054 | 0.71 | MTOR (0.48) | MTORRPTORMLST8PARP1SMN1; SMN2 | |
| SCHEMBL20141263 | 0.71 | MTOR (0.46) | MTORRPTORMLST8PARP1 | |
| SCHEMBL20141443 | 0.70 | MTOR (0.45) | MTORRPTORMLST8SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |