Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879892 | 0.90 | MTNR1A (0.69) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL16150685 | 0.88 | MAPT (0.47) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL7960876 | 0.87 | F10 (0.50) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL24187458 | 0.86 | MTNR1A (0.46) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL15563812 | 0.86 | DRD2 (0.44) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL29153650 | 0.85 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL4929242 | 0.83 | MTNR1A (0.60) | MTNR1AMTNR1BKMT2A | |
| SCHEMBL16150853 | 0.82 | MAPT (0.45) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL2982156 | 0.81 | MTNR1A (0.42) | MTNR1AMTNR1BKDM4ESMN1; SMN2CRHBP | |
| SCHEMBL24187366 | 0.81 | KDM4E (0.60) | KDM4ESMN1; SMN2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |