Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | Q9HBH1 | 1/20 | 0.33 | |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11844785 | 0.96 | GPR84 (0.42) | GPR84MAPK1CA2MAPTL3MBTL1 | |
| SCHEMBL499960 | 0.85 | POLB (0.40) | GPR84MAPK1MAPTL3MBTL1NPSR1 | |
| SCHEMBL10885050 | 0.81 | SLC6A3 (0.45) | CA2SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL6212936 | 0.79 | GPR84 (0.40) | GPR84MAPK1CA2FFAR4FFAR1 | |
| SCHEMBL6214649 | 0.79 | HTT (0.38) | GPR84MAPK1CA2MAPTL3MBTL1 | |
| SCHEMBL10025245 | 0.77 | SLC6A3 (0.49) | MAPK1CA2MAPTL3MBTL1NPSR1 | |
| SCHEMBL25922001 | 0.77 | HRH3 (0.37) | MAPTSLC6A2SLC6A3ALDH1A1SIGMAR1 | |
| SCHEMBL25922002 | 0.77 | HRH3 (0.37) | MAPTSLC6A2SLC6A3ALDH1A1SIGMAR1 | |
| SCHEMBL500155 | 0.76 | DPP7 (0.35) | MAPK1SLC6A2SLC6A3TDP1 | |
| SCHEMBL10566713 | 0.76 | SLC6A3 (0.48) | MAPK1MAPTL3MBTL1NPSR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538526-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089355-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |