Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 5/20 | 0.50 |
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140709 | 1.00 | GRM1 (0.50) | GRM1MTORRPTORMLST8HSD11B1 | |
| SCHEMBL20141860 | 0.91 | GRM1 (0.47) | GRM1MTORRPTORMLST8HSD11B1 | |
| SCHEMBL20139963 | 0.87 | GRM1 (0.54) | GRM1MTORRPTORMLST8HSD11B1 | |
| SCHEMBL20140280 | 0.86 | GRM1 (0.45) | GRM1MTORRPTORMLST8CHRM4 | |
| SCHEMBL20142818 | 0.86 | GRM1 (0.45) | GRM1MTORRPTORMLST8CHRM4 | |
| SCHEMBL20139885 | 0.86 | MTOR (0.44) | GRM1MTORRPTORMLST8KMT2A | |
| SCHEMBL20141878 | 0.86 | MTOR (0.44) | GRM1MTORRPTORMLST8KMT2A | |
| SCHEMBL20140629 | 0.85 | CHRM2 (0.49) | GRM1MTORRPTORMLST8KMT2A | |
| SCHEMBL20140128 | 0.83 | GRM1 (0.45) | GRM1MTORRPTORMLST8HSD11B1 | |
| SCHEMBL20140024 | 0.82 | GRM1 (0.43) | GRM1HSD11B1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |