Sugi Predict

Sugi Predict / Compounds / SCHEMBL20142278

SCHEMBL20142278

SCHEMBL20142278

CCCCCCCCN(C)C(C)C

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ DNM1 Q05193 5/20 0.55
▸ TSHR P16473 2/20 0.42
▸ THRB P10828 1/20 0.42
▸ GGPS1 O95749 3/20 0.39
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ S1PR2 O95136 1/20 0.38
▸ S1PR1 P21453 1/20 0.38
▸ S1PR3 Q99500 1/20 0.38
▸ S1PR5 Q9H228 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20142325 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL20142242 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL20142376 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL7589367 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL20142505 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL10464715 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL19992803 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL20142869 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL21126454 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12
SCHEMBL15006368 1.00 DNM1 (0.55) DNM1TSHRTHRBGGPS1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538575-B1 HIGH CIS-1,4 BLOCK COPOLYMERS OF POLYBUTADIENE AND POLYISOPRENE BRIDGESTONE CORP (JP) 2024-03-13 — — EP disclosed
US-11884767-B2 High cis-1,4 block copolymers of polybutadiene and polyisoprene BRIDGESTONE CORPORATION (JP) 2024-01-30 — — US disclosed
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-25 — — US disclosed
US-11807636-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-11-07 — — US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 — — US disclosed
WO-2023141635-A2 HER3 LIGANDS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-07-27 — — WO disclosed
US-20230227454-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE SHIONOGI & CO., LTD. (JP) 2023-07-20 — — US disclosed
US-20230219945-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-13 — — US disclosed
US-11679109-B2 SMARCA degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-06-20 — — US disclosed
US-20230158150-A1 COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF NOVARTIS AG (CH) 2023-05-25 — — US disclosed
US-20230149549-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-18 — — US disclosed
US-20220119573-A1 HIGH CIS-1,4 BLOCK COPOLYMERS OF POLYBUTADIENE AND POLYISOPRENE BRIDGESTONE CORPORATION (JP) 2022-04-21 — — US disclosed
US-11230622-B2 High cis-1,4 block copolymers of polybutadiene and polyisoprene BRIDGESTONE CORPORATION (JP) 2022-01-25 — — US disclosed
US-20210388196-A1 GENE DELIVERY CARRIER MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2021-12-16 — — US disclosed
US-11117889-B1 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2021-09-14 — — US disclosed
EP-3538575-A1 HIGH CIS-1,4 BLOCK COPOLYMERS OF POLYBUTADIENE AND POLYISOPRENE Bridgestone Corporation (JP) 2019-09-18 — — EP disclosed
WO-2018089635-A1 HIGH CIS-1,4 BLOCK COPOLYMERS OF POLYBUTADIENE AND POLYISOPRENE BRIDGESTONE CORPORATION (JP) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 DNM1 3545/4885TSHR 4388/4885THRB 4304/4885
US-20230227454-A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE IDH3B, CCNA1, CCNB1 DNM1 1687/4885TSHR 1210/4885THRB 766/4885
US-20230158150-A1 COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF NSUN2, NSUN3, POLM DNM1 1040/4885TSHR 2560/4885THRB 2737/4885
US-11117889-B1 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 DNM1 4044/4885TSHR 3319/4885THRB 1824/4885
US-20230149549-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCB1, SMARCE1 DNM1 2849/4885TSHR 4066/4885THRB 3751/4885
US-20210388196-A1 GENE DELIVERY CARRIER PAICS, PBDC1, BCAT1 DNM1 4619/4885TSHR 3794/4885THRB 2797/4885
US-20230219945-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 DNM1 4044/4885TSHR 3319/4885THRB 1824/4885
US-11807636-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 DNM1 4044/4885TSHR 3319/4885THRB 1824/4885
US-11679109-B2 SMARCA degraders and uses thereof SMARCA1, SMARCA2, SMARCC2 DNM1 3545/4885TSHR 4388/4885THRB 4304/4885
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 DNM1 4044/4885TSHR 3319/4885THRB 1824/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.