SCHEMBL20142514

SCHEMBL20142514

O=C(O)CCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.68

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 8/20 0.68
DDB1 Q16531 6/20 0.68
HDAC3 O15379 4/20 0.67
HDAC1 Q13547 4/20 0.67
HDAC2 Q92769 4/20 0.67
NCOR2 Q9Y618 4/20 0.67
STAT3 P40763 2/20 0.65
CA2 P00918 2/20 0.59
MIF P14174 3/20 0.58
BCL2 P10415 3/20 0.58
MCL1 Q07820 3/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869200 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL22325167 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL20242290 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL21333201 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL30189563 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL20242552 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL22326316 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL22834201 1.00 CRBN (0.68) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL21179283 0.99 CRBN (0.69) CRBNDDB1HDAC3HDAC1HDAC2
SCHEMBL30189483 0.99 CRBN (0.69) CRBNDDB1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4734989-A2 SYNTHESIS AND IN VITRO CHARACTERIZATION OF PROTEOLYSIS TARGETING CHIMERAS (PROTACS) FOR DEGRADATION OF DNA METHYLTRANSFERASE 1 (DNMT1) Dana-Farber Cancer Institute, Inc. (US) 2026-05-06 EP disclosed
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
US-20260115297-A1 HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF HPK1 ICAHN SCHOOL MED MOUNT SINAI (US) 2026-04-30 US disclosed
US-12569563-B2 Selective HDAC6 degraders and methods of use thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-03-10 US disclosed
EP-3725771-B1 ALK PROTEIN DEGRADATION AGENT AND ANTI-TUMOR APPLICATION THEREOF UNIV SHANGHAI TECHNOLOGY (CN) 2026-02-04 EP disclosed
US-20260028342-A1 ENHANCING ANTIMETASTASIS ACTIVITY USING TARGETED PROTEIN DEGRADATION UNIV NORTH CAROLINA CHAPEL HILL (US) 2026-01-29 US disclosed
US-12528814-B2 Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof NURIX THERAPEUTICS, INC. (US) 2026-01-20 US disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
US-12465648-B2 Heterobifunctional compounds as degraders of HPK1 ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2025-11-11 US disclosed
EP-3551185-A1 COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER Icahn School of Medicine at Mount Sinai (US) 2019-10-16 EP disclosed
WO-2019170150-A1 PROTEIN DEGRADATION TARGETING BCR-ABL COMPOUND AND ANTITUMOR APPLICATION THEREOF 上海科技大学 2019-09-12 WO disclosed
WO-2019165189-A1 PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) DEGRADATION / DISRUPTION COMPOUNDS AND METHODS OF USE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2019-08-29 WO disclosed
WO-2019165189-A1 PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) DEGRADATION / DISRUPTION COMPOUNDS AND METHODS OF USE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2019-08-29 WO disclosed
US-20190255041-A1 COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 2019-08-22 US disclosed
WO-2019149922-A1 COMPOUNDS WHICH CAUSE DEGRADATION OF EGFR, FOR USE AGAINST CANCER F. HOFFMANN-LA ROCHE AG (CH) 2019-08-08 WO disclosed
WO-2019144117-A1 BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT BIOVENTURES, LLC (US) 2019-07-25 WO disclosed
WO-2018106870-A1 COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2018-06-14 WO disclosed
WO-2018106870-A1 COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2018-06-14 WO disclosed
WO-2018089736-A1 DEGRADATION OF PROTEIN KINASES BY CONJUGATION OF PROTEIN KINASE INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2018-05-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12465648-B2 Heterobifunctional compounds as degraders of HPK1 HIPK1, MCL1, HYPK CRBN 421/4885DDB1 473/4885HDAC3 1077/4885
US-12528814-B2 Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof IRAK1, IRAK2, IRAK3 CRBN 71/4885DDB1 519/4885HDAC3 229/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 CRBN 149/4885DDB1 1222/4885HDAC3 180/4885
US-20260028342-A1 ENHANCING ANTIMETASTASIS ACTIVITY USING TARGETED PROTEIN DEGRADATION EEF1A2, EEF1E1, EEF1D CRBN 3862/4885DDB1 1069/4885HDAC3 3381/4885
US-20260115297-A1 HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF HPK1 TTK, ITK, CLK1 CRBN 1072/4885DDB1 2640/4885HDAC3 1359/4885
US-12569563-B2 Selective HDAC6 degraders and methods of use thereof HDAC6, HDAC1, HDAC11 CRBN 405/4885DDB1 1138/4885HDAC3 4/4885
US-20190255041-A1 COMPOSITIONS AND METHODS FOR TREATING EZH2-MEDIATED CANCER EZH2, EZH1, EED CRBN 120/4885DDB1 350/4885HDAC3 64/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.