Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862421 | 0.79 | LMNA (0.36) | PDE2ALMNA | |
| SCHEMBL1231007 | 0.79 | PDE2A (0.31) | PDE2A | |
| SCHEMBL27535345 | 0.75 | HRH1 (0.37) | LMNA | |
| SCHEMBL1028713 | 0.74 | FAAH (0.30) | LMNA | |
| SCHEMBL7983483 | 0.72 | PDE2A (0.53) | PDE2ALMNAKCNH2TP53 | |
| SCHEMBL20237842 | 0.72 | PDE2A (0.53) | PDE2ALMNAKCNH2TP53 | |
| SCHEMBL29669152 | 0.72 | PDE2A (0.53) | PDE2ALMNAKCNH2TP53 | |
| SCHEMBL160259 | 0.71 | — | — | |
| SCHEMBL16055953 | 0.71 | PDE2A (0.43) | PDE2ALMNATP53 | |
| SCHEMBL28056399 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | claimed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | claimed |