Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142844 | 0.91 | MAPT (0.57) | CCNA2CDK2KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL20142432 | 0.85 | CCNA2 (0.80) | CCNA2CDK2RAB9AMAPTLMNA | |
| SCHEMBL20142094 | 0.85 | RAB9A (0.50) | CCNA2CDK2KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL20142185 | 0.84 | CDK5 (0.60) | CCNA2CDK2MAPTLMNANPC1 | |
| SCHEMBL20142492 | 0.82 | GSK3A (0.57) | CCNA2CDK2KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL20142189 | 0.81 | CCNA2 (0.52) | CCNA2CDK2KDM4EMAPTLMNA | |
| SCHEMBL20142179 | 0.77 | GSK3A (0.53) | RAB9ASMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL20142841 | 0.77 | MAPT (0.63) | CCNA2CDK2RAB9ASMN1; SMN2MAPT | |
| SCHEMBL20142835 | 0.76 | GSK3A (0.57) | CCNA2CDK2RAB9ASMN1; SMN2MAPT | |
| SCHEMBL20142200 | 0.75 | CCNA2 (0.81) | CCNA2CDK2RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |