Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | LDLR | P01130 | 3/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442438 | 0.91 | EPHB2 (0.45) | EPHB2ABL1BCRRAF1MAPK13 | |
| SCHEMBL16283149 | 0.88 | MAPK13 (0.44) | EPHB2ABL1BCRRAF1MAPK13 | |
| SCHEMBL12858730 | 0.77 | LDLR (0.60) | EPHB2ABL1BCRKITDDR2 | |
| SCHEMBL1824198 | 0.75 | NR2E1 (0.43) | MAPK13NR2E1 | |
| SCHEMBL3343040 | 0.75 | NR2E1 (0.48) | KMT2AMEN1RAB9AMAPTTDP1 | |
| SCHEMBL13659898 | 0.73 | NR2E1 (0.77) | EPHB2ABL1BCRKITPDGFRB | |
| SCHEMBL4254144 | 0.71 | NR2E1 (0.73) | EPHB2ABL1BCRRAF1KIT | |
| SCHEMBL15442444 | 0.70 | NR2E1 (0.49) | MAPK13TDP1NR2E1 | |
| SCHEMBL9701793 | 0.69 | NR2E1 (0.48) | RAB9AMAPTTDP1NPC1NR2E1 | |
| SCHEMBL3343037 | 0.69 | PDE4A (0.44) | MAPK13TDP1NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |