Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442444 | 0.88 | NR2E1 (0.49) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL9701793 | 0.86 | NR2E1 (0.48) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL1824198 | 0.81 | NR2E1 (0.43) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL3405576 | 0.80 | NR2E1 (0.56) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL3344599 | 0.80 | KMT2A (0.51) | CYP3A4CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL22394099 | 0.79 | CYP1A2 (0.46) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL27985278 | 0.79 | CYP1A2 (0.65) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL264998 | 0.78 | CYP1A2 (0.56) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL15222204 | 0.78 | MAOA (0.50) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 | |
| SCHEMBL1824196 | 0.78 | CYP3A4 (0.46) | NR2E1CYP3A4CYP1A2CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | NR2E1 382/4885CYP3A4 1590/4885CYP1A2 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.