Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | LDLR | P01130 | 2/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442438 | 0.93 | EPHB2 (0.45) | MAPK13LDLRPCSK9NR2E1EPHB2 | |
| SCHEMBL20144342 | 0.88 | EPHB2 (0.46) | MAPK13LDLRPCSK9NR2E1EPHB2 | |
| SCHEMBL1824198 | 0.74 | NR2E1 (0.43) | MAPK13NR2E1PDE4APDE4BPDE4C | |
| SCHEMBL15442444 | 0.72 | NR2E1 (0.49) | MAPK13NR2E1PDE4APDE4BPDE4C | |
| SCHEMBL30217888 | 0.70 | IP6K1 (0.49) | NR2E1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9701793 | 0.68 | NR2E1 (0.48) | NR2E1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3343040 | 0.68 | NR2E1 (0.48) | NR2E1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL589522 | 0.68 | NR2E1 (0.73) | LDLRPCSK9NR2E1EPHB2ABL1 | |
| SCHEMBL29493483 | 0.68 | NR2E1 (0.73) | LDLRPCSK9NR2E1EPHB2ABL1 | |
| SCHEMBL3712352 | 0.67 | PDE4A (0.58) | LDLRPCSK9NR2E1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174996-B2 | Protein kinase inhibitors | ASTAR BIOTECH LLC (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364436-A1 | Protein Kinase Inhibitors | ASTAR BIOTECH LLC (US) | 2014-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364436-A1 | Protein Kinase Inhibitors | MAP3K9, MAP3K6, MAP3K8 | MAPK13 92/4885LDLR 2760/4885PCSK9 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.