Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | APP | P05067 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.59 |
| ▸ | FDPS | P14324 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | IAPP | P10997 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16976570 | 0.92 | JUN (0.73) | JUNNFKB1APPFDPSGAA | |
| SCHEMBL2219674 | 0.90 | NFKB1 (0.85) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL2294213 | 0.88 | JUN (0.68) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL31256668 | 0.88 | JUN (0.68) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL2294216 | 0.88 | JUN (0.68) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL5934912 | 0.87 | JUN (0.66) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL30964227 | 0.87 | JUN (0.66) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL7017036 | 0.87 | JUN (0.66) | JUNNFKB1ALOX5GAAHTT | |
| Hydrochloric Acid SCHEMBL8830740 | 0.87 | JUN (0.66) | JUNNFKB1ALOX5GAAHTT | |
| SCHEMBL28541317 | 0.87 | JUN (0.66) | JUNNFKB1ALOX5GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10703729-B2 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO LTD (CN) | 2020-07-07 | — | — | US | disclosed |
| US-20190276413-A1 | Pyrazine derivative, and preparation method and medical use thereof | GUANGZHOU MAGPIE PHARMACEUTICALS CO., LTD. (CN) | 2019-09-12 | — | — | US | disclosed |
| EP-3321259-A1 | NEW PYRAZINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL APPLICATION THEREOF | Guangzhou Magpie Pharmaceutical Co., Ltd. (CN) | 2018-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190276413-A1 | Pyrazine derivative, and preparation method and medical use thereof | RYR2, RYR1, ORAI1 | JUN 1003/4885NFKB1 1184/4885APP 9/4885 |
| US-10703729-B2 | Pyrazine derivative, and preparation method and medical use thereof | RYR2, RYR1, ORAI1 | JUN 1003/4885NFKB1 1184/4885APP 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.