Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081846 | 0.89 | TSHR (0.43) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL30103910 | 0.87 | TSHR (0.44) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL26316991 | 0.87 | TSHR (0.44) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL11828641 | 0.86 | ADRA2A (0.43) | TSHRKMT2AMEN1HCAR2ELANE | |
| Ethylene Glycol SCHEMBL11963064 | 0.85 | TSHR (0.40) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL14771654 | 0.83 | TSHR (0.46) | TSHRKMT2AMEN1ELANELMNA | |
| SCHEMBL22474203 | 0.83 | CYP3A4 (0.47) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL538486 | 0.81 | HCAR2 (0.54) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL9231000 | 0.81 | HCAR2 (0.54) | TSHRKMT2AMEN1HCAR2ELANE | |
| SCHEMBL22474290 | 0.80 | MTNR1A (0.42) | TSHRKMT2AMEN1ELANELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |