Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acoramidis. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR known ✓ | P02766 | 6/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acoramidis SCHEMBL15816954 | 1.00 | TTR (1.00) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| Acoramidis SCHEMBL29390976 | 0.99 | TTR (0.98) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| Acoramidis SCHEMBL20475239 | 0.99 | TTR (0.98) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL15832081 | 0.98 | TTR (0.95) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL24953188 | 0.91 | TTR (0.83) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL17525272 | 0.91 | TTR (0.83) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL17522783 | 0.90 | TTR (0.81) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL15816998 | 0.90 | TTR (0.81) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL15816962 | 0.89 | TTR (1.00) | TTRALBSMN1; SMN2HSD17B10MAPT | |
| SCHEMBL17522791 | 0.88 | TTR (0.94) | TTRALBSMN1; SMN2HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 584 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056844-A | AG10 formulations | 文涵治疗有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-20260097014-A1 | FORMULATIONS OF AG10 | EIDOS THERAPEUTICS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260010773-A1 | TEMPORAL DYNAMICS SIMULATION IN MATMUL-FREE NEURAL ARCHITECTURES | LEPTUDE INC (US) | 2026-01-08 | — | — | US | claimed |
| WO-2025235883-A1 | ACORAMIDIS FOR USE IN THE TREATMENT OF RENAL DYSFUNCTION | Eidos Therapeutics, Inc. (US) | 2025-11-13 | — | — | WO | claimed |
| EP-3836920-B1 | FORMULATIONS OF AG10 | EIDOS THERAPEUTICS INC (US) | 2025-10-01 | — | — | EP | claimed |
| US-12385107-B2 | Process for the recovery and recycling of materials that constitute supported palladium membranes | HYDROGEN ONSITE, S.L. (ES) | 2025-08-12 | — | — | US | claimed |
| WO-2025104243-A1 | ANTI-TRANSTHYRETIN ANTIBODY, COMPOSITIONS COMPRISING SAID ANTIBODY AND METHODS FOR TREATING OR PREVENTING TRANSTHYRETIN-MEDIATED AMYLOIDOSIS | NEURIMMUNE AG (CH) | 2025-05-22 | — | — | WO | claimed |
| CN-114062519-B | Method for separating and detecting dichloro-hydantoin | 广东东阳光药业股份有限公司 | 2025-04-15 | — | — | CN | claimed |
| WO-2025067526-A1 | CULTIVATION METHOD FOR HERBICIDE-RESISTANT, INSECT-RESISTANT, AND STRESS-TOLERANT SOYBEANS JINGDOU 632 AND JINGDOU 633, AND USE THEREOF | 中国农业科学院作物科学研究所 | 2025-04-03 | — | — | WO | claimed |
| WO-2025067527-A1 | CULTIVATION METHOD FOR HERBICIDE-RESISTANT, INSECT-RESISTANT, AND STRESS-TOLERANT SOYBEANS JINGDOU 625 AND JINGDOU 626, AND USE THEREOF | 中国农业科学院作物科学研究所 | 2025-04-03 | — | — | WO | claimed |
| US-20220185993-A1 | MIXED COMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | claimed |
| US-20220184041-A1 | (AZA)Benzothiazolyl Substituted Pyrazole Compounds | PFIZER INC. (US) | 2022-06-16 | — | — | US | claimed |
| CN-114630685-A | Calcium carbonate composition for medical use, related composition for medical use, and method for producing same | 石川邦夫 | 2022-06-14 | — | — | CN | claimed |
| WO-2022112919-A1 | (AZA)BENZOTHIAZOLYL SUBSTITUTED PYRAZOLE COMPOUNDS | PFIZER INC. (US) | 2022-06-02 | — | — | WO | claimed |
| CN-114509572-A | Quantitative evaluation method for drug effect of amyloidosis drug | 大连润生康泰医学检验实验室有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-114374979-A | Method and device for determining isolation distance between RLAN station and radar system in 5GHz frequency band | 北京邮电大学 | 2022-04-19 | — | — | CN | claimed |
| CN-113493594-B | Alloy material for 3D printing and preparation method thereof | 同济大学 | 2022-04-05 | — | — | CN | claimed |
| US-11260047-B2 | Formulations of AG10 | Eidos Therapeutics, Inc. (US) | 2022-03-01 | — | — | US | claimed |
| CN-114062519-A | Method for separating and detecting dichlorohydantoin | 广东东阳光药业有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-113955131-A | Data intelligent monitoring processing platform for health state of manned aircraft | 山东欧龙电子科技有限公司 | 2022-01-21 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260010773-A1 | TEMPORAL DYNAMICS SIMULATION IN MATMUL-FREE NEURAL ARCHITECTURES | NES, NCSTN, CHAT | TTR 933/4885ALB 788/4885SMN1; SMN2 84/4885 |
| US-11260047-B2 | Formulations of AG10 | ATXN10, RAB10, HDAC10 | TTR 410/4885ALB 317/4885SMN1; SMN2 3021/4885 |
| US-20220184041-A1 | (AZA)Benzothiazolyl Substituted Pyrazole Compounds | TTR, APOB, SERPINB6 | TTR 1/4885ALB 6/4885SMN1; SMN2 872/4885 |
| US-20260097014-A1 | FORMULATIONS OF AG10 | ATXN10, STARD10, S100A10 | TTR 367/4885ALB 235/4885SMN1; SMN2 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.