Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29419304 | 0.78 | — | — | |
| SCHEMBL1398128 | 0.76 | NOS3 (0.39) | PDE3BPDE3ASMN1; SMN2GAAHTR5A | |
| SCHEMBL10354186 | 0.69 | PDE3B (0.41) | PDE3BPDE3ASMN1; SMN2GAAPARP10 | |
| SCHEMBL19142252 | 0.69 | ADRA2A (0.36) | PDE3BPDE3ASMN1; SMN2GAAPARP10 | |
| SCHEMBL13844803 | 0.69 | PDE3B (0.41) | PDE3BPDE3ATDP1 | |
| SCHEMBL19257866 | 0.69 | — | — | |
| SCHEMBL14294948 | 0.69 | HTR5A (0.43) | PDE3BPDE3AGAAPARP10PARP11 | |
| SCHEMBL2616770 | 0.68 | PDE3B (0.41) | PDE3BPDE3ASMN1; SMN2GAAPARP10 | |
| SCHEMBL2616781 | 0.65 | PDE3B (0.39) | PDE3BPDE3ASMN1; SMN2GAAPARP10 | |
| SCHEMBL30149404 | 0.65 | PDE3B (0.39) | PDE3BPDE3ASMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321261-A1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | Curis, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |