Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147362 | 0.89 | DPP4 (0.35) | PARP1CYP2D6DPP4DPP7MMP1 | |
| SCHEMBL20069560 | 0.85 | CYP2D6 (0.35) | PARP1CYP2D6DPP4MMP1MMP9 | |
| SCHEMBL18705063 | 0.82 | MMP9 (0.33) | PARP1CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL20147468 | 0.81 | RET (0.34) | CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL20069778 | 0.80 | RET (0.36) | PARP1CYP2D6DPP4DPP7 | |
| SCHEMBL20201374 | 0.79 | MMP1 (0.32) | CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL20148046 | 0.78 | RET (0.34) | CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL16304087 | 0.76 | DRD2 (0.37) | PARP1CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL20147324 | 0.76 | MMP9 (0.36) | CYP2D6MMP1MMP9MMP13 | |
| SCHEMBL20070401 | 0.74 | CYP2D6 (0.34) | PARP1CYP2D6MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133207-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | PARP1 3054/4885CYP2D6 3759/4885DPP4 1963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.