Sugi Predict

Sugi Predict / Compounds / SCHEMBL20147461

SCHEMBL20147461

SCHEMBL20147461

CC(C)N1CCC(Oc2ccc(C(F)(F)F)cn2)CC1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ LIPE Q05469 9/20 0.57
▸ HRH3 Q9Y5N1 6/20 0.54
▸ LIPG Q9Y5X9 1/20 0.51
▸ SCN9A Q15858 1/20 0.45
▸ EPHX2 P34913 1/20 0.45
▸ HSD11B1 P28845 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30589668 0.84 LIPE (0.53) LIPEHRH3LIPGEPHX2HSD11B1
SCHEMBL2924533 0.84 HRH3 (0.57) LIPEHRH3LIPGSCN9AEPHX2
SCHEMBL2924536 0.84 HRH3 (0.57) LIPEHRH3LIPGSCN9AEPHX2
SCHEMBL20070180 0.83 LIPE (0.57) LIPELIPGEPHX2HSD11B1
SCHEMBL20070188 0.83 LIPE (0.56) LIPEHRH3LIPGEPHX2HSD11B1
SCHEMBL20147458 0.82 HRH3 (0.56) LIPEHRH3
SCHEMBL20145199 0.82 LIPE (0.55) LIPELIPGEPHX2HSD11B1
SCHEMBL18855867 0.81 LIPE (0.53) LIPELIPGEPHX2HSD11B1
SCHEMBL12026424 0.80 HRH3 (0.61) HRH3
SCHEMBL29202405 0.80 LIPE (0.56) LIPELIPGEPHX2HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-01-05 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 LIPE 4758/4885HRH3 1000/4885LIPG 4689/4885
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 LIPE 4758/4885HRH3 1000/4885LIPG 4689/4885
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 LIPE 4758/4885HRH3 1000/4885LIPG 4689/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 LIPE 4758/4885HRH3 1000/4885LIPG 4689/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 LIPE 4758/4885HRH3 1000/4885LIPG 4689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.