Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 9/20 | 0.55 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144750 | 0.92 | IL1B (0.55) | LIPELIPGIL1BNLRP3HSD11B1 | |
| SCHEMBL20145221 | 0.92 | IL1B (0.55) | LIPELIPGIL1BNLRP3HSD11B1 | |
| SCHEMBL18855867 | 0.85 | LIPE (0.53) | LIPELIPGHSD11B1EPHX2SMN1; SMN2 | |
| SCHEMBL30755072 | 0.83 | LIPE (0.52) | LIPELIPGHSD11B1EPHX2SMN1; SMN2 | |
| SCHEMBL16839482 | 0.83 | LIPE (0.52) | LIPELIPGHSD11B1EPHX2SMN1; SMN2 | |
| SCHEMBL20147461 | 0.82 | LIPE (0.57) | LIPELIPGHSD11B1EPHX2 | |
| SCHEMBL20070180 | 0.81 | LIPE (0.57) | LIPELIPGHSD11B1EPHX2 | |
| SCHEMBL12425916 | 0.81 | LIPE (0.52) | LIPELIPGHSD11B1HCRTR1EPHX2 | |
| SCHEMBL20070188 | 0.81 | LIPE (0.56) | LIPELIPGHSD11B1EPHX2 | |
| SCHEMBL20145106 | 0.80 | LIPG (0.53) | LIPELIPGHSD11B1HCRTR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |